Clinical Case Reports (Mar 2021)

NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling

  • Heidi M. Britton,
  • Adrian B. Levine,
  • Yaoqing Shen,
  • Karen Mungall,
  • Jonathan Serrano,
  • Matija Snuderl,
  • Erin Pleasance,
  • Steven J. M. Jones,
  • Janessa Laskin,
  • Marco A. Marra,
  • Shahrad R. Rassekh,
  • Rebecca Deyell,
  • Stephen Yip,
  • Sylvia Cheng,
  • Chris Dunham

DOI
https://doi.org/10.1002/ccr3.3804
Journal volume & issue
Vol. 9, no. 3
pp. 1472 – 1477

Abstract

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Abstract This is the first report of a NACC2‐NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been identified through routine diagnostics, demonstrating the value of clinical genome profiling in cancer care.