CircSETDB1 knockdown inhibits the malignant progression of serous ovarian cancer through miR-129-3p-dependent regulation of MAP3K3

Abstract

Highlights 1. CircSETDB1 expression was increased in SOC tissues and cells. 2. CircSETDB1 silencing repressed the malignancy of SOC cells. 3. CircSETDB1 mediated SOC malignant progression by interacting with miR-129-3p. 4. MAP3K3 served as a target gene of miR-129-3p. 5. CircSETDB1 knockdown inhibited tumor formation in vivo.

Keywords

• SOC
• circSETDB1
• miR-129-3p
• MAP3K3