Crystal structure of human METTL6, the m3C methyltransferase

Ran Chen; Jie Zhou; Ling Liu; Xue-Ling Mao; Xiaolong Zhou; Wei Xie

doi:10.1038/s42003-021-02890-9

Communications Biology (Dec 2021)

Crystal structure of human METTL6, the m3C methyltransferase

Ran Chen,
Jie Zhou,
Ling Liu,
Xue-Ling Mao,
Xiaolong Zhou,
Wei Xie

Affiliations

Ran Chen: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, The Sun Yat-Sen University
Jie Zhou: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, The Sun Yat-Sen University
Ling Liu: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, The Sun Yat-Sen University
Xue-Ling Mao: State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Xiaolong Zhou: State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Wei Xie: MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, The Sun Yat-Sen University

DOI: https://doi.org/10.1038/s42003-021-02890-9
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 10

Abstract

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Ran Chen et al. report the crystal structure of human m3C methyltrasfease METTL6. They generate structure models of hMETTL6 in complex with substrates, providing important insight into the molecular recognition mechanism by METTL6 and may aid in the METTL-based rational drug design in the future.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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