Standardized use of a combined topical preparation in the complex treatment of thrombophlebitis of the superficial veins of the lower extremities

Abstract

Introduction. Treatment of thrombophlebitis should be complex and, along with mandatory compression, include both systemic and local use of drugs.Aim. To evaluate the efficacy and safety of the standardized use of the combined drug indomethacin/troxerutin in gel in real clinical practice in the treatment of superficial vein thrombophlebitis.Materials and methods. The study included 71 patients with varicose veins complicated by superficial vein thrombophlebitis. In group I patients (n = 35), topical drugs were not used. In group II patients (n = 36), combined drug indomethacin/troxerutin in gel was used daily. The drug was applied to the skin of the lower extremities three times a day, 4–5 cm of gel. Its total daily amount did not exceed 20 cm of gel. The observation period was 10 days. A dynamic scoring of clinical symptoms was performed using a linear analog scale and thermometry of the skin of the lower extremities.Results. On day 10, patients of the main group showed a statistically significant decrease in thermographic parameters in the area of thrombophlebitis: Tmin – 33.23 ± 0.12 °C, Tmax – 39.86 ± 0.24 °C, Tmean – 40.01 ± 0.16 °C (p ≤ 0.05). When assessing the symptoms of thrombophlebitis using a linear analog scale after 10 days of treatment, there was a general decrease in the number of points in the control group to 16.4 ± 0.12 and in the main group to 12.3 ± 0.16 points (p ≤ 0.05).Conclusion. Combined drug indomethacin/troxerutin in gel is an effective and safe combined drug for the treatment of patients with thrombophlebitis of the superficial veins of the lower extremities.

Keywords

• хронические заболевания вен
• хроническая венозная недостаточность
• варикозная болезнь
• топические лекарственные средства
• троксерутин
• индометацин