Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury

Jing Mu; Chunxiao Li; Yu Shi; Guoyong Liu; Jianhua Zou; Dong-Yang Zhang; Chao Jiang; Xiuli Wang; Liangcan He; Peng Huang; Yuxin Yin; Xiaoyuan Chen

doi:10.1038/s41467-022-29772-w

Nature Communications (May 2022)

Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury

Jing Mu,
Chunxiao Li,
Yu Shi,
Guoyong Liu,
Jianhua Zou,
Dong-Yang Zhang,
Chao Jiang,
Xiuli Wang,
Liangcan He,
Peng Huang,
Yuxin Yin,
Xiaoyuan Chen

Affiliations

Jing Mu: Institute of Precision Medicine, Peking University Shenzhen Hospital
Chunxiao Li: Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University
Yu Shi: Institute of Precision Medicine, Peking University Shenzhen Hospital
Guoyong Liu: Institute of Precision Medicine, Peking University Shenzhen Hospital
Jianhua Zou: Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore
Dong-Yang Zhang: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Health Science Center, Shenzhen University
Chao Jiang: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Health Science Center, Shenzhen University
Xiuli Wang: Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University
Liangcan He: School of Medicine and Health, Harbin Institute of Technology
Peng Huang: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Health Science Center, Shenzhen University
Yuxin Yin: Institute of Precision Medicine, Peking University Shenzhen Hospital
Xiaoyuan Chen: Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore

DOI: https://doi.org/10.1038/s41467-022-29772-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Pharmacological interventions against hepatic ischemia-reperfusion injury remain limited. Here, the authors provide a nanotherapeutics-based solution combining reactive oxygen species scavenging and nitric oxide modulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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