Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health

Elleke Tissink; Siemon C. de Lange; Jeanne E. Savage; Douglas P. Wightman; Christiaan A. de Leeuw; Kristen M. Kelly; Mats Nagel; Martijn P. van den Heuvel; Danielle Posthuma

doi:10.1038/s42003-022-03672-7

Communications Biology (Jul 2022)

Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health

Elleke Tissink,
Siemon C. de Lange,
Jeanne E. Savage,
Douglas P. Wightman,
Christiaan A. de Leeuw,
Kristen M. Kelly,
Mats Nagel,
Martijn P. van den Heuvel,
Danielle Posthuma

Affiliations

Elleke Tissink: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience
Siemon C. de Lange: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience
Jeanne E. Savage: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience
Douglas P. Wightman: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience
Christiaan A. de Leeuw: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience
Kristen M. Kelly: Institute for Behavioral Genetics, University of Colorado Boulder
Mats Nagel: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience
Martijn P. van den Heuvel: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience
Danielle Posthuma: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience

DOI: https://doi.org/10.1038/s42003-022-03672-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

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A genome-wide association study on MRI cerebellar volume in the UK Biobank cohort identifies 30 loci with genome-wide significance that might be relevant to brain structure and cognitive function.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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