Distribution characteristics of serum 25-hydroxyvitamin D levels in patients with first-episode drug-naive depressive disorders

Abstract

Objective To retrospectively analyze the serum levels of 25-hydroxyvitamin D [25（OH）D] in patients with drug-naive depression and its correlation with gender and age， compare with their counterparts with other mental disorders to guide clinical work. Methods A total of 1583 drug-naive patients with mental illness were enrolled. The gender， age， diagnosis， and serum 25（OH）D value of all patients were recorded. Serum 25（OH）D levels were compared between depression patients and those with other mental disorders， and compared among depression patients of different genders and ages. Results Serum 25（OH）D level in patients with depressive disorders was higher than that in those with bipolar disorders， whereas lower than those in their counterparts with organic mental disorders， schizophrenia， anxiety disorders， and sleep disorders （all P < 0.05）. Serum 25（OH）D level was deficient in 55.7%， insufficient in 37.0% and sufficient in 7.4% of patients with depressive disorders. Serum 25（OH）D level in female patients was lower than that in male counterparts （P < 0.001）. Serum 25（OH）D level in juvenile patients was lower than that in elderly counterparts （P < 0.001）. Conclusions Serum 25（OH）D level in patients with depressive disorder differs from those in their counterparts with other mental disorders， prompting that the role of serum 25（OH）D in the episode and prognosis of depressive disorders deserves further investigation. Serum 25（OH）D deficiency and insufficiency are common in patients with depressive disorders， especially in female and juvenile patients. These findings suggest that it is necessary to deliver screening of serum 25（OH）D level in these populations and supplement vitamin D in a timely manner.

Keywords

• |depressive disorder|serum 25-hydroxyvitamin d|gender|age|bipolar disorder