Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation

Lingdi Nie; Dongqing Ma; John P. Quinn; Minyan Wang

doi:10.1186/s10194-021-01359-8

The Journal of Headache and Pain (Dec 2021)

Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation

Lingdi Nie,
Dongqing Ma,
John P. Quinn,
Minyan Wang

Affiliations

Lingdi Nie: Department of Biological Sciences, Centre for Neuroscience, Xi’an Jiaotong-Liverpool University (XJTLU)
Dongqing Ma: Department of Biological Sciences, Centre for Neuroscience, Xi’an Jiaotong-Liverpool University (XJTLU)
John P. Quinn: Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology
Minyan Wang: Department of Biological Sciences, Centre for Neuroscience, Xi’an Jiaotong-Liverpool University (XJTLU)

DOI: https://doi.org/10.1186/s10194-021-01359-8
Journal volume & issue: Vol. 22, no. 1
pp. 1 – 14

Abstract

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Highlights • SFKs activity-mediated P2X7 receptor signaling facilitates CSD propagation via glutamatergic pathway and also promotes neuroinflammation. • P2X7 receptor/SFKs signaling can be targeted for migraine prophylaxis and therapy.

Published in The Journal of Headache and Pain

ISSN: 1129-2369 (Print); 1129-2377 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://thejournalofheadacheandpain.biomedcentral.com/

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Abstract

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