Nature Communications (Apr 2022)

A cryptic pocket in Ebola VP35 allosterically controls RNA binding

  • Matthew A. Cruz,
  • Thomas E. Frederick,
  • Upasana L. Mallimadugula,
  • Sukrit Singh,
  • Neha Vithani,
  • Maxwell I. Zimmerman,
  • Justin R. Porter,
  • Katelyn E. Moeder,
  • Gaya K. Amarasinghe,
  • Gregory R. Bowman

DOI
https://doi.org/10.1038/s41467-022-29927-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 10

Abstract

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Many viral proteins are thought to be unlikely candidates for drug discovery as they lack obvious drug binding sites. Here, the authors use computational approaches followed by experimental validation to identify a cryptic pocket within the Ebola virus protein VP35.