Nature Communications (Sep 2020)

Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway

  • Vasilisa Aksenova,
  • Alexandra Smith,
  • Hangnoh Lee,
  • Prasanna Bhat,
  • Caroline Esnault,
  • Shane Chen,
  • James Iben,
  • Ross Kaufhold,
  • Ka Chun Yau,
  • Carlos Echeverria,
  • Beatriz Fontoura,
  • Alexei Arnaoutov,
  • Mary Dasso

DOI
https://doi.org/10.1038/s41467-020-18266-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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mRNAs export from the nucleus is thought to be regulated in part by three nucleoporins that comprise the nuclear basket, but whether and how distinct basket nucleoporins interact with the RNA export machinery is unclear. Here, the authors use rapid auxin-mediated degradation of basket nucleoporins Nup153, Nup50, and Tpr, and see that Tpr interacts with the TREX-2 mRNA export complex.