Revista Brasileira de Reumatologia ()

Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients

  • Sherif Taha,
  • Sherif Mohammed Gamal,
  • Mohamed Nabil,
  • Nahla Naeem,
  • Dalia Labib,
  • Ibrahim Siam,
  • Tamer Atef Gheita

DOI
https://doi.org/10.1016/j.rbre.2016.11.007
Journal volume & issue
Vol. 57, no. 2
pp. 149 – 153

Abstract

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Abstract Aim: To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations. Patients and methods: Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without. For both groups the SNP G1612A (rs10434) of the VEGF gene was genotyped by real time polymerase chain reaction (RT-PCR). Results: Statistically significant difference was found in genotype and allele frequencies between both groups (AA [70% vs 13.3%, p < 0.001] and GG [10% vs 66.7%, p < 0.001]). Conclusion: Polymorphism in the gene coding for VEGF may be associated with increased incidence of neuropsychiatric lupus in SLE patients.

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