Successful Deferasirox Rechallenge and Treating Through Reaction in a Patient with Challenge-Proven Mild Immediate Reaction: A Case Report

Abstract

Mongkhon Sompornrattanaphan,1 Thanachit Krikeerati,1,2 Chamard Wongsa,1 Torpong Thongngarm,1 Kittika Yampayon3 1Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 3Adverse Drug Reaction (ADR) Unit, Pharmacy Department, Siriraj Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Kittika YampayonAdverse Drug Reaction (ADR) Unit, Pharmacy Department, Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok Noi, Bangkok 10700, ThailandTel [phone]Fax [phone]Email [email protected]: This is the first report of successful deferasirox administration, using graded challenge and treating through, in a patient with mild immediate hypersensitivity reaction. Beginning with drug graded challenges could indicate the eliciting dose and reaction severity which are important for the management plan in the next step. This approach could be a safe shortcut in a stable patient with a mild reaction and a long avoidance period.Keywords: deferasirox, drug allergy, rechallenge, desensitization, hypersensitivity, iron overload, iron chelating agents, thalassemia, premedication

Keywords

• dfx
• deferasirox
• drug allergy
• rechallenge
• desensitization
• hypersensitivity
• iron overload
• iron chelating agents
• thalassemia
• premedication
• histamine h1 antagonists