Nature Communications (May 2018)
IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE
- Shu Wang,
- Jingya Wang,
- Varsha Kumar,
- Jodi L. Karnell,
- Brian Naiman,
- Phillip S. Gross,
- Saifur Rahman,
- Kamelia Zerrouki,
- Richard Hanna,
- Christopher Morehouse,
- Nicholas Holoweckyj,
- Hao Liu,
- Autoimmunity Molecular Medicine Team,
- Zerai Manna,
- Raphaela Goldbach-Mansky,
- Sarfaraz Hasni,
- Richard Siegel,
- Miguel Sanjuan,
- Katie Streicher,
- Michael P. Cancro,
- Roland Kolbeck,
- Rachel Ettinger
Affiliations
- Shu Wang
- Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC
- Jingya Wang
- Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC
- Varsha Kumar
- Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC
- Jodi L. Karnell
- Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC
- Brian Naiman
- Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC
- Phillip S. Gross
- Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC
- Saifur Rahman
- Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC
- Kamelia Zerrouki
- Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC
- Richard Hanna
- Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC
- Christopher Morehouse
- Translational Medicine, MedImmune LLC
- Nicholas Holoweckyj
- Translational Medicine, MedImmune LLC
- Hao Liu
- Translational Medicine, MedImmune LLC
- Autoimmunity Molecular Medicine Team
- Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC
- Zerai Manna
- The Office of Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
- Raphaela Goldbach-Mansky
- National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Sarfaraz Hasni
- The Office of Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
- Richard Siegel
- The Office of Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
- Miguel Sanjuan
- Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC
- Katie Streicher
- Translational Medicine, MedImmune LLC
- Michael P. Cancro
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Roland Kolbeck
- Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC
- Rachel Ettinger
- Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC
- DOI
- https://doi.org/10.1038/s41467-018-03750-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Systemic lupus erythematosus (SLE) is associated with altered B cell responses but the underlying aetiology is still unclear. Here the authors show that a CD11chiT-bet+ B cell subset with a unique phenotype and transcriptome is increased in patients with SLE, can be expanded by IL-21, and may contribute to autoimmune responses in SLE.
