GAK and PRKCD are positive regulators of PRKN-independent mitophagy

Michael J. Munson; Benan J. Mathai; Matthew Yoke Wui Ng; Laura Trachsel-Moncho; Laura R. de la Ballina; Sebastian W. Schultz; Yahyah Aman; Alf H. Lystad; Sakshi Singh; Sachin Singh; Jørgen Wesche; Evandro F. Fang; Anne Simonsen

doi:10.1038/s41467-021-26331-7

Nature Communications (Oct 2021)

GAK and PRKCD are positive regulators of PRKN-independent mitophagy

Michael J. Munson,
Benan J. Mathai,
Matthew Yoke Wui Ng,
Laura Trachsel-Moncho,
Laura R. de la Ballina,
Sebastian W. Schultz,
Yahyah Aman,
Alf H. Lystad,
Sakshi Singh,
Sachin Singh,
Jørgen Wesche,
Evandro F. Fang,
Anne Simonsen

Affiliations

Michael J. Munson: Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
Benan J. Mathai: Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
Matthew Yoke Wui Ng: Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
Laura Trachsel-Moncho: Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
Laura R. de la Ballina: Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
Sebastian W. Schultz: Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
Yahyah Aman: Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital
Alf H. Lystad: Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
Sakshi Singh: Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
Sachin Singh: Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
Jørgen Wesche: Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
Evandro F. Fang: Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital
Anne Simonsen: Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo

DOI: https://doi.org/10.1038/s41467-021-26331-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 22

Abstract

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The mechanisms involved in programmed or damage-induced removal of mitochondria by mitophagy remain elusive. Here the authors use an siRNA library to screen lipid-binding proteins, and identify the kinases GAK and PRKCD as positive regulators of PRKN-independent mitophagy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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