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Targeted screening for congenital cytomegalovirus infection in infants who fail universal newborn hearing screen.

Revista ORL. 2019;10(4):253-261 DOI 10.14201/orl.21117


Journal Homepage

Journal Title: Revista ORL

ISSN: 2444-7986 (Online)

Publisher: Ediciones Universidad de Salamanca

Society/Institution: Universidad de Salamanca

LCC Subject Category: Medicine: Otorhinolaryngology

Country of publisher: Spain

Language of fulltext: Spanish

Full-text formats available: PDF



José Ignacio BENITO-OREJAS (SACYL, Hospital Clínico Universitario de Valladolid, España)

Fernando BENITO-GONZÁLEZ (SACYL, Complejo Asistencial Universitario de Salamanca, España)

Fernando GARCÍA-VICARIO (SACYL, Complejo Asistencial Universitario de Burgos, España)

Gerardo MARTÍN-SIGÜENZA (SACYL, Complejo Asistencial Universitario de León, España)

María REY-MARCOS (SACYL, Complejo Asistencial de Segovia, España)

María Luisa SERRANO-MADRID (SACYL, Complejo Asistencial de Soria, España)

Elisa GIL-CARCEDO-SAÑUDO (SACYL, Hospital Universitario Río Hortega de Valladolid, España)

Jesús SAN-ROMÁN-CARBAJO (SACYL, Hospital El Bierzo de Ponferrada, España)

Laura CURIESES-BECERRIL (SACYL, Complejo Asistencial Universitario de Palencia, España)

Victor Manuel MARUGÁN-ISABEL (SACYL, Complejo Asistencial de Zamora, España)


Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 4 weeks


Abstract | Full Text

Introduction: Given the importance of early antiviral treatment in infants with sensorineural hearing loss secondary to congenital cytomegalovirus infection (cCMV), we submit a protocol for early diagnosis of cCMV according to the outcome of universal newborn hearing screening using automated auditory brainstem responses (AABR) (targeted CMV screening). Material and methods: Based on current knowledge provides by literature, we elaborate an action algorithm agreed between the coordinators of the Early Hearing Detection and Intervention program in Castilla y León (Spain). Results: If the first AABR test is a refer result for one or both ears, we request the identification of the viral genome by PCR in a urine sample within 15 days. The confirmation of uni or bilateral sensorineural hearing loss, allows the beginning of the antiviral treatment, before the first month of life. Discussion: Universal screening of cCMV enables monitoring of all infected infants, identifying cases of late-onset/progressive hearing loss sooner; but in the presence of an unknown cause- sensorineural hearing loss from the first two weeks of life, efforts must be made to rule out cCMV infection, although it is more complicated under these conditions. Conclusion: The inclusion of cCMV diagnosis into neonatal hearing screening program, will allow early detection of congenital infection in some infants, improving their quality of life.