Nature Communications (Jul 2018)
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis
- Mark S. Gresnigt,
- Cristina Cunha,
- Martin Jaeger,
- Samuel M. Gonçalves,
- R. K. Subbarao Malireddi,
- Anne Ammerdorffer,
- Rosalie Lubbers,
- Marije Oosting,
- Orhan Rasid,
- Grégory Jouvion,
- Catherine Fitting,
- Dirk J. de Jong,
- João F. Lacerda,
- António Campos,
- Willem J. G. Melchers,
- Katrien Lagrou,
- Johan Maertens,
- Thirumala-Devi Kanneganti,
- Agostinho Carvalho,
- Oumaima Ibrahim-Granet,
- Frank L. van de Veerdonk
Affiliations
- Mark S. Gresnigt
- Cytokines & Inflammation, Institut Pasteur
- Cristina Cunha
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Martin Jaeger
- Department of Experimental Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center
- Samuel M. Gonçalves
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- R. K. Subbarao Malireddi
- Department of Immunology, St. Jude Children’s Research Hospital
- Anne Ammerdorffer
- Department of Experimental Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center
- Rosalie Lubbers
- Department of Experimental Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center
- Marije Oosting
- Department of Experimental Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center
- Orhan Rasid
- Cytokines & Inflammation, Institut Pasteur
- Grégory Jouvion
- Département Infection et Epidémiologie, Unité Histopathologie Humaine et Modèles Animaux, Institut Pasteur
- Catherine Fitting
- Cytokines & Inflammation, Institut Pasteur
- Dirk J. de Jong
- Department of Gastroenterology and Hepatology, Radboud University Medical Center
- João F. Lacerda
- Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Universidade de Lisboa
- António Campos
- Serviço de Transplantação de Medula Óssea (STMO), Instituto Português de Oncologia do Porto, Rua Dr. António Bernardino de Almeida
- Willem J. G. Melchers
- Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands
- Katrien Lagrou
- Department of Microbiology and Immunology, KU Leuven
- Johan Maertens
- Department of Microbiology and Immunology, KU Leuven
- Thirumala-Devi Kanneganti
- Department of Immunology, St. Jude Children’s Research Hospital
- Agostinho Carvalho
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Oumaima Ibrahim-Granet
- Cytokines & Inflammation, Institut Pasteur
- Frank L. van de Veerdonk
- Department of Experimental Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center
- DOI
- https://doi.org/10.1038/s41467-018-04912-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
NOD2 has been shown to be crucial for immune recognition of Aspergillus infection. Here the authors show that a common NOD2 genetic variant associated with Crohn’s disease is associated with reduced risk of disease due to enhanced antifungal activates of monocytes and macrophages.
