Adipose‐Derived Mesenchymal Stem Cells Ameliorate Lipid Metabolic Disturbance in Mice

Abstract

Adipose‐derived mesenchymal stem cells (AD‐MSCs) have been shown to ameliorate hyperglycemia in diabetic animals and individuals. However, little is known about whether AD‐MSCs affect lipid metabolism. Here we have demonstrated for the first time that AD‐MSC infusion can significantly suppress the increase in body weight and remarkably improve dyslipidemia in db/db obese mice and diet‐induced obesity mice. Induction of white fat tissue “browning” and activation of adenosine monophosphate‐activated protein kinase and its downstream hormone‐sensitive lipase in adipose tissue contribute to the antiobesity and lipid‐lowering effects. Thus, AD‐MSC infusion holds great therapeutic potential for dyslipidemia and associated cardiovascular diseases.

Keywords

• Adipose‐derived mesenchymal stem cell
• Anti‐obesity
• Lipid metabolism
• Adenosine monophosphate-activated protein kinase