A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: <i>Cdc</i>PDE, a Rattlesnake Phosphodiesterase

Isadora Oliveira; Victor Costa; Flávio Veras; Isabela Ferreira; Fernando Cunha; Thiago Cunha; Wuelton Monteiro; Eliane Arantes; Manuela Pucca

doi:10.3390/toxins15010044

Toxins (Jan 2023)

A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: <i>Cdc</i>PDE, a Rattlesnake Phosphodiesterase

Isadora Oliveira,
Victor Costa,
Flávio Veras,
Isabela Ferreira,
Fernando Cunha,
Thiago Cunha,
Wuelton Monteiro,
Eliane Arantes,
Manuela Pucca

Affiliations

Isadora Oliveira: Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, SP, Brazil
Victor Costa: Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil
Flávio Veras: Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil
Isabela Ferreira: Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, SP, Brazil
Fernando Cunha: Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil
Thiago Cunha: Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil
Wuelton Monteiro: School of Health Sciences, Amazonas State University, Manaus 69850-000, AM, Brazil
Eliane Arantes: Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, SP, Brazil
Manuela Pucca: Medical School, Federal University of Roraima, Boa Vista 69310-000, RR, Brazil

DOI: https://doi.org/10.3390/toxins15010044
Journal volume & issue: Vol. 15, no. 1
p. 44

Abstract

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Neutrophil extracellular traps (NETs) are an important mechanism for defense against pathogens. Their overproduction can be harmful since excessive NET formation promotes inflammation and tissue damage in several diseases. Nucleases are capable to degrade NET on basis of their DNA hydrolysis activity, including the CdcPDE, a nuclease isolated from Crotalus durissus collilineatus snake venom. Here, we report a new finding about CdcPDE activity, demonstrating its efficiency in degrading cell-free DNA from NETs, being a potential candidate to assist in therapies targeting inflammatory diseases.

Published in Toxins

ISSN: 2072-6651 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/toxins/

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