Nature Communications (Feb 2021)

Dysregulated transcriptional responses to SARS-CoV-2 in the periphery

  • Micah T. McClain,
  • Florica J. Constantine,
  • Ricardo Henao,
  • Yiling Liu,
  • Ephraim L. Tsalik,
  • Thomas W. Burke,
  • Julie M. Steinbrink,
  • Elizabeth Petzold,
  • Bradly P. Nicholson,
  • Robert Rolfe,
  • Bryan D. Kraft,
  • Matthew S. Kelly,
  • Daniel R. Saban,
  • Chen Yu,
  • Xiling Shen,
  • Emily M. Ko,
  • Gregory D. Sempowski,
  • Thomas N. Denny,
  • Geoffrey S. Ginsburg,
  • Christopher W. Woods

DOI
https://doi.org/10.1038/s41467-021-21289-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 8

Abstract

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The systemic immune features that distinguish COVID-19 from common infections remain incompletely elucidated. Here McClain et al. compare RNA sequencing in peripheral blood between subjects with SARS-CoV-2 and other respiratory infections and demonstrate dysregulated immune responses in COVID-19 with both heterogeneous and conserved components.