Examination of Oxidative Stress Markers in Women with Postmenopausal Osteoporosis

Abstract

Objective: Postmenopausal osteoporosis a disease with increased fracture tendency in the bones based upon reduced bone mineral density. Oxidative stress is an important risk factor for osteoporosis. In our study, it was aimed to investigate the levels of oxidative stress markers in women with postmenopausal osteoporosis. Materials and Methods: In postmenopausal women with and without osteoporosis and also in healthy controls; the bone mineral density, routine laboratory tests, 25-hydroxyvitamin D3, malondialdehyde, protein carbonyl and total antioxidant capacity levels were measured. Malondialdehyde levels were measured by the ELISA method, protein carbonyl and total antioxidant capacity levels by the colorimetric method. Results: Malondialdehyde levels were found to decrease in both postmenopausal groups, protein carbonyl levels increased in postmenopausal group without osteoporosis. Conclusion: These results make it difficult to establish a relationship between osteoporosis and oxidative stress. We think that measurement of more specific antioxidant and oxidant molecules will contribute to the issue.

Keywords

• Osteoporosis
• bone mineral density
• oxidative stress