Clinical Ophthalmology (Jun 2022)
Liposomal Ozonated Oil in Ocular Infections: A Review of Preclinical and Clinical Studies, Focusing on Its Antiseptic and Regenerative Properties
Abstract
Juan J Pérez-Santonja,1 José Luis Güell,2 Oscar Gris,2 Xose Manuel Vázquez Dorrego,3 Esther Pellicer,4 Jose Manuel Benítez-Del-Castillo5– 7 1Department of Ophthalmology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain; 2Department of Cornea and Refractive Surgery, Institut de Microcirurgia Ocular (IMO), Barcelona, Spain; 3Department of Ophthalmology, Hospital Municipal de Badalona, Badalona (Barcelona), Spain; 4EPT Servicios Científicos, Barcelona, Spain; 5Department of Ophthalmology, Hospital Clínico San Carlos de Madrid, Madrid, Spain; 6Universidad Complutense de Madrid, Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Madrid, Spain; 7Clínica Rementería, Madrid, SpainCorrespondence: Jose Manuel Benítez-Del-Castillo, Hospital Clinico San Carlos, C/ Martin Lagos s/n, Madrid, 28040, Spain, Tel +34 913303000, Fax +34 913941359, Email [email protected]: Ozonated oil has shown antimicrobial, anti-inflammatory and regenerative properties that make it useful in the prevention of infectious diseases and also as an adjuvant in wound-healing management. This review brings together most aspects of the use of liposomal ozonated oil for ocular infections and regeneration of the ocular surface. A search was performed in PubMed, Medline, Web of Science and Cochrane Library for studies published by June 2021. Search terms were combined to sort out papers on the properties and use of ozonated oil in ocular infections. A total of 25 publications were selected for this review on the composition, mechanism of action, restorative action, and preclinical and clinical studies of liposomal ozonated oil focused on ocular infections. In patients with complicated corneal pathology, liposomal ozonated oil has been found to restore corneal ulcers and improve keratitis. In patients with ocular pathologies involving inflammation and infections, liposomal ozonated oil has been found to improve and almost completely restore the signs of vernal, granulomatous and even adenoviral conjunctivitis. Liposomal ozonated oil has also been found to be effective in reducing ocular microbial flora. In conclusion, liposomal ozonated oil has an antiseptic and regenerative effect on corneoconjunctival tissues. It has demonstrated efficacy and safety profile for its use in ocular infections and can be considered as a suitable supportive strategy both alone and combined with other antimicrobial agents.Keywords: antifungal, antimicrobial, antiviral, liposomal ozonated oil, restorative action
