Nature Communications (Jan 2019)
The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis
- S. A. Baechler,
- V. M. Factor,
- I. Dalla Rosa,
- A. Ravji,
- D. Becker,
- S. Khiati,
- L. M. Miller Jenkins,
- M. Lang,
- C. Sourbier,
- S. A. Michaels,
- L. M. Neckers,
- H. L. Zhang,
- A. Spinazzola,
- S. N. Huang,
- J. U. Marquardt,
- Y. Pommier
Affiliations
- S. A. Baechler
- Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NIH, National Cancer Institute
- V. M. Factor
- Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NIH, National Cancer Institute
- I. Dalla Rosa
- Department of Clinical and Movement Neurosciences, Institute of Neurology, Royal Free Campus, University College London
- A. Ravji
- Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NIH, National Cancer Institute
- D. Becker
- Department of Medicine I, Johannes Gutenberg University
- S. Khiati
- Equipe MitoLab, Institut MitoVasc, UMR CNRS 6015, INSERM U1083, Universite d’Angers
- L. M. Miller Jenkins
- Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- M. Lang
- Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- C. Sourbier
- Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- S. A. Michaels
- Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NIH, National Cancer Institute
- L. M. Neckers
- Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- H. L. Zhang
- Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NIH, National Cancer Institute
- A. Spinazzola
- Department of Clinical and Movement Neurosciences, Institute of Neurology, Royal Free Campus, University College London
- S. N. Huang
- Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NIH, National Cancer Institute
- J. U. Marquardt
- Department of Medicine I, Johannes Gutenberg University
- Y. Pommier
- Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NIH, National Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-018-07922-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
TOP1MT is a topoisomerase that is localised to mitochondria. Here, the authors show that TOP1MT has a tumor promoting role in hepatocellular carcinoma by supporting mitochondrial translation and that its deficiency limits tumorigenicity.
