Nature Communications (Sep 2019)
Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
- Julian Musa,
- Florencia Cidre-Aranaz,
- Marie-Ming Aynaud,
- Martin F. Orth,
- Maximilian M. L. Knott,
- Olivier Mirabeau,
- Gal Mazor,
- Mor Varon,
- Tilman L. B. Hölting,
- Sandrine Grossetête,
- Moritz Gartlgruber,
- Didier Surdez,
- Julia S. Gerke,
- Shunya Ohmura,
- Aruna Marchetto,
- Marlene Dallmayer,
- Michaela C. Baldauf,
- Stefanie Stein,
- Giuseppina Sannino,
- Jing Li,
- Laura Romero-Pérez,
- Frank Westermann,
- Wolfgang Hartmann,
- Uta Dirksen,
- Melissa Gymrek,
- Nathaniel D. Anderson,
- Adam Shlien,
- Barak Rotblat,
- Thomas Kirchner,
- Olivier Delattre,
- Thomas G. P. Grünewald
Affiliations
- Julian Musa
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Florencia Cidre-Aranaz
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Marie-Ming Aynaud
- INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre
- Martin F. Orth
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Maximilian M. L. Knott
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Olivier Mirabeau
- INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre
- Gal Mazor
- Department of Life Sciences, Ben-Gurion University of the Negev
- Mor Varon
- Department of Life Sciences, Ben-Gurion University of the Negev
- Tilman L. B. Hölting
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Sandrine Grossetête
- INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre
- Moritz Gartlgruber
- Neuroblastoma Genomics, German Cancer Research Center (DKFZ)
- Didier Surdez
- INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre
- Julia S. Gerke
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Shunya Ohmura
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Aruna Marchetto
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Marlene Dallmayer
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Michaela C. Baldauf
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Stefanie Stein
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Giuseppina Sannino
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Jing Li
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Laura Romero-Pérez
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Frank Westermann
- Neuroblastoma Genomics, German Cancer Research Center (DKFZ)
- Wolfgang Hartmann
- Division of Translational Pathology, Gerhard-Domagk Institute of Pathology, University Hospital of Münster
- Uta Dirksen
- Department of Pediatric Hematology and Oncology, University Hospital of Essen
- Melissa Gymrek
- Department of Medicine, University of California, San Diego
- Nathaniel D. Anderson
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Adam Shlien
- Program in Genetics and Genome Biology, The Hospital for Sick Children
- Barak Rotblat
- Department of Life Sciences, Ben-Gurion University of the Negev
- Thomas Kirchner
- Institute of Pathology, Faculty of Medicine, LMU Munich
- Olivier Delattre
- INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre
- Thomas G. P. Grünewald
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- DOI
- https://doi.org/10.1038/s41467-019-12071-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Interactions between germline variants and somatic mutations is a relatively unexplored topic in cancer. Here, in Ewing sarcoma, the authors show that binding of the oncogenic EWSR1-FLI1 fusion transcription factor to a polymorphic enhancer-like DNA element controls MYBL2, whose high expression correlates with prognosis.
