Royal Jelly Suppresses Invasive Potential of Colorectal Cancer Cells by Attenuating Vimentin and Snail

Abstract

Royal jelly (RJ), as an exclusive bee product, showed beneficial effects on various human pathological conditions, including cancer. Therefore, we examined the effects of RJ on the suppression of invasiveness of SW-480 cells and protein expression of Vimentin and Snail, markers of cancer cell invasive properties. This natural treatment suppressed the aggressive behavior of tested cells by inhibiting the expression of transcription factor Snail, and consequently the expression of cytoskeletal protein Vimentin with a key role in supporting invasive potential. In conclusion, our report indicates the possible molecular mechanism of anti-invasive activity of RJ on the colorectal carcinoma cell line via the inhibition of Vimentin and Snail protein expression.

Keywords

• immunofluorescence
• SW-480 cell line
• Transwell
• apitherapy
• transcription factor