SIGNIFICANCE OF PROGNOSTIC FACTORS IN THE MULTIMODALITY TREATMENT OF SUPRATENTORIAL INFILTRATIVE LOW-GRADE GLIOMAS

Abstract

Background. Objectives: analysis of the most important prognostic factors for progression-free survival (PFS) in patients with low-grade cerebral gliomas (LGG). material and methods. 107 patients with morphologically proven low-grade cerebral gliomas were included into the study. There were 57 (53.3 %) patients with diffuse astrocytoma, 14 (13.1 %) with oligoastrocytoma and 36 (33.6 %) patients with oligodendroglioma. Results. Risk factors included age ≥40 years, diffuse astrocytoma, tumor size of more than 6 cm, displacement of the midbrain structures and severe or moderate neurological deficit. Acute cerebral circulatory disorder and the extent of surgical excision of the tumor did not effect on the outcome of LGG treatment. The highest rates of PFS were observed in patients with stage T3 disease and the lowest PFS rates in patients with stage III disease. Conclusion. Significant risk factors should be considered in planning multi-modality treatment for low grade cerebral gliomas.

Keywords

• low-grade cerebral gliomas
• prognostic factors
• tumor stages
• acute cerebral circulatory disorder
• progression-free survival