Nature Communications (Feb 2018)

A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors

  • Rabia Mateen,
  • M. Monsur Ali,
  • Todd Hoare

DOI
https://doi.org/10.1038/s41467-018-02956-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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False positive results significantly slow down the drug discovery process. Here, the authors developed a gel serving as a screening platform in which enzymes can be stored, stabilized, and protected from most of the compounds that typically cause these misleading results.