Xin yixue (Oct 2023)

RSRC1 inhibits the proliferation and metastasis of ESCC by targeting PTEN/PI3K/AKT pathway

  • Zhou Jiatian, Shang Guansheng, Zhang Cong, Jiang Dexiong, Yuan Dongdong, Tang Dengyao, Zhou Jiang

DOI
https://doi.org/10.3969/j.issn.0253-9802.2023.10.012
Journal volume & issue
Vol. 54, no. 10
pp. 749 – 753

Abstract

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Objective To explore the role of arginine-and serine-rich coiled coil 1（RSRC1） in the proliferation and metastasis of esophageal squamous cell carcinoma（ESCC）. Methods The expression of PTEN in ESCC was detected by biogenic analysis. The expression of RSRC1 in ESCC cells was detected by qRT-PCR and Western blot（WB）. The effect of RSRC1 on the proliferation and metastasis of ESCC cells was elucidated by CCK-8， cell migration and invasion tests. The expression of related factors in PTEN/PI3K/AKT signaling pathway was analyzed by WB. Results The biogenic analysis showed that PTEN was low in ESCC tissue. Molecular experiments showed low expression of RSRC1 in ESCC cells. Cell experiments showed that RSRC1 knockdown can promote ESCC proliferation and metastasis， and can regulate PTEN/PI3K/AKT signaling pathway. Conclusion RSRC1 inhibits ESCC proliferation and metastasis through targeted regulation of PTEN/PI3K/AKT pathway. RSRC1 may be a new diagnostic marker and therapeutic target for ESCC.

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