Computational and Structural Biotechnology Journal (Jan 2022)
Addressing the clinical unmet needs in primary Sjögren’s Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts
- Vasileios C. Pezoulas,
- Andreas Goules,
- Fanis Kalatzis,
- Luke Chatzis,
- Konstantina D. Kourou,
- Aliki Venetsanopoulou,
- Themis P. Exarchos,
- Saviana Gandolfo,
- Konstantinos Votis,
- Evi Zampeli,
- Jan Burmeister,
- Thorsten May,
- Manuel Marcelino Pérez,
- Iryna Lishchuk,
- Thymios Chondrogiannis,
- Vassiliki Andronikou,
- Theodora Varvarigou,
- Nenad Filipovic,
- Manolis Tsiknakis,
- Chiara Baldini,
- Michele Bombardieri,
- Hendrika Bootsma,
- Simon J. Bowman,
- Muhammad Shahnawaz Soyfoo,
- Dorian Parisis,
- Christine Delporte,
- Valérie Devauchelle-Pensec,
- Jacques-Olivier Pers,
- Thomas Dörner,
- Elena Bartoloni,
- Roberto Gerli,
- Roberto Giacomelli,
- Roland Jonsson,
- Wan-Fai Ng,
- Roberta Priori,
- Manuel Ramos-Casals,
- Kathy Sivils,
- Fotini Skopouli,
- Witte Torsten,
- Joel A. G. van Roon,
- Mariette Xavier,
- Salvatore De Vita,
- Athanasios G. Tzioufas,
- Dimitrios I. Fotiadis
Affiliations
- Vasileios C. Pezoulas
- Unit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, Greece
- Andreas Goules
- Dept. of Pathophysiology, School of Medicine, University of Athens, Athens, Greece
- Fanis Kalatzis
- Unit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, Greece
- Luke Chatzis
- Dept. of Pathophysiology, School of Medicine, University of Athens, Athens, Greece
- Konstantina D. Kourou
- Unit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, Greece
- Aliki Venetsanopoulou
- Dept. of Pathophysiology, School of Medicine, University of Athens, Athens, Greece; University Hospital of Ioannina, Ioannina, Greece
- Themis P. Exarchos
- Unit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, Greece; Dept. of Informatics, Ionian University, Corfu, Greece
- Saviana Gandolfo
- Clinic of Rheumatology, Dept. of Medical and Biological Sciences, Udine University, Udine, Italy
- Konstantinos Votis
- Centre for Research and Technology Hellas, Thermi, Thessaloniki, Greece
- Evi Zampeli
- Institute for Systemic Autoimmune and Neurological Diseases, Athens, Greece
- Jan Burmeister
- Fraunhofer Institute for Computer Graphics Research IGD, Darmstadt, Germany
- Thorsten May
- Fraunhofer Institute for Computer Graphics Research IGD, Darmstadt, Germany
- Manuel Marcelino Pérez
- ATOS, Madrid, Spain
- Iryna Lishchuk
- Institute of Legal Informatics, Leibniz Universität Hannover, Hannover, Germany
- Thymios Chondrogiannis
- Institute of Communication and Computer Systems, School of Electrical and Computer Engineering, National and Technical University of Athens, Athens, Greece
- Vassiliki Andronikou
- Institute of Communication and Computer Systems, School of Electrical and Computer Engineering, National and Technical University of Athens, Athens, Greece
- Theodora Varvarigou
- Institute of Communication and Computer Systems, School of Electrical and Computer Engineering, National and Technical University of Athens, Athens, Greece
- Nenad Filipovic
- Bioengineering Research and Development Center, Faculty of Engineering, University of Kragujevac, Kragujevac, Serbia
- Manolis Tsiknakis
- Biomedical Informatics and eHealth Laboratory, Dept. of Electrical and Computer Engineering, Hellenic Mediterranean University, Heraklion, Greece
- Chiara Baldini
- Dept. of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
- Michele Bombardieri
- Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London and Barts’ Health NHS Trust, London, United Kingdom
- Hendrika Bootsma
- Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, the Netherlands
- Simon J. Bowman
- Rheumatology Dept., University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
- Muhammad Shahnawaz Soyfoo
- Dept. of Rheumatology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium
- Dorian Parisis
- Laboratory of Pathophysiological Biochemistry and Nutrition, Université Libre de Bruxelles, Brussels, Belgium
- Christine Delporte
- Laboratory of Pathophysiological Biochemistry and Nutrition, Université Libre de Bruxelles, Brussels, Belgium
- Valérie Devauchelle-Pensec
- Univ Brest, Inserm, CHU de Brest, UMR1227, Lymphocytes B et Autoimmunité, Brest, France
- Jacques-Olivier Pers
- Univ Brest, Inserm, CHU de Brest, UMR1227, Lymphocytes B et Autoimmunité, Brest, France
- Thomas Dörner
- Dept. of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany
- Elena Bartoloni
- Rheumatology Unit, Dept. of Medicine and Surgery, University of Perugia, Perugia, Italy
- Roberto Gerli
- Rheumatology Unit, Dept. of Medicine and Surgery, University of Perugia, Perugia, Italy
- Roberto Giacomelli
- Division of Rheumatology, Dept. of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy
- Roland Jonsson
- Dept. of Clinical Science, University of Bergen, Bergen, Norway
- Wan-Fai Ng
- Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
- Roberta Priori
- Dept. of Internal Medicine and Medical Specialties, Rheumatology Clinic, Sapienza University of Rome, Rome, Italy
- Manuel Ramos-Casals
- Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Barcelona, Spain
- Kathy Sivils
- Oklahoma Medical Research Foundation, OK, US
- Fotini Skopouli
- Institute for Systemic Autoimmune and Neurological Diseases, Athens, Greece; Dept. of Internal Medicine and Clinical Immunology, Euroclinic Hospital, Athens, Greece
- Witte Torsten
- Dept. of Rheumatology and Immunology, Hanover Medical School, Hanover, Germany
- Joel A. G. van Roon
- Dept. of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
- Mariette Xavier
- Dept. of Rheumatology, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Paris, France
- Salvatore De Vita
- Clinic of Rheumatology, Dept. of Medical and Biological Sciences, Udine University, Udine, Italy
- Athanasios G. Tzioufas
- Dept. of Pathophysiology, School of Medicine, University of Athens, Athens, Greece
- Dimitrios I. Fotiadis
- Unit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, Greece; Dept. of Biomedical Research, FORTH-IMBB, Ioannina, Greece; Corresponding author.
- Journal volume & issue
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Vol. 20
pp. 471 – 484
Abstract
For many decades, the clinical unmet needs of primary Sjögren’s Syndrome (pSS) have been left unresolved due to the rareness of the disease and the complexity of the underlying pathogenic mechanisms, including the pSS-associated lymphomagenesis process. Here, we present the HarmonicSS cloud-computing exemplar which offers beyond the state-of-the-art data analytics services to address the pSS clinical unmet needs, including the development of lymphoma classification models and the identification of biomarkers for lymphomagenesis. The users of the platform have been able to successfully interlink, curate, and harmonize 21 regional, national, and international European cohorts of 7,551 pSS patients with respect to the ethical and legal issues for data sharing. Federated AI algorithms were trained across the harmonized databases, with reduced execution time complexity, yielding robust lymphoma classification models with 85% accuracy, 81.25% sensitivity, 85.4% specificity along with 5 biomarkers for lymphoma development. To our knowledge, this is the first GDPR compliant platform that provides federated AI services to address the pSS clinical unmet needs.
