<i>Salvia rosmarinus</i> Spenn. (Lamiaceae) Hydroalcoholic Extract: Phytochemical Analysis, Antioxidant Activity and In Vitro Evaluation of Fatty Acid Accumulation
Vincenzo Musolino,
Roberta Macrì,
Antonio Cardamone,
Luigi Tucci,
Maria Serra,
Carmine Lupia,
Samantha Maurotti,
Rosario Mare,
Saverio Nucera,
Lorenza Guarnieri,
Mariangela Marrelli,
Anna Rita Coppoletta,
Cristina Carresi,
Micaela Gliozzi,
Vincenzo Mollace
Affiliations
Vincenzo Musolino
Laboratory of Pharmaceutical Biology, Department of Health Sciences, Institute of Research for Food Safety and Health IRC-FSH, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
Roberta Macrì
Department of Health Sciences, Institute of Research for Food Safety and Health IRC-FSH, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
Antonio Cardamone
Department of Health Sciences, Institute of Research for Food Safety and Health IRC-FSH, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
Luigi Tucci
H&AD Srl, 89032 Bianco, Italy
Maria Serra
Department of Health Sciences, Institute of Research for Food Safety and Health IRC-FSH, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
Carmine Lupia
Department of Health Sciences, Institute of Research for Food Safety and Health IRC-FSH, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
Samantha Maurotti
Department of Clinical and Experimental Medicine, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
Rosario Mare
Department of Clinical and Experimental Medicine, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
Saverio Nucera
Department of Health Sciences, Institute of Research for Food Safety and Health IRC-FSH, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
Lorenza Guarnieri
Department of Health Sciences, Institute of Research for Food Safety and Health IRC-FSH, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
Mariangela Marrelli
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
Anna Rita Coppoletta
Department of Health Sciences, Institute of Research for Food Safety and Health IRC-FSH, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
Cristina Carresi
Veterinary Pharmacology Laboratory, Department of Health Sciences, Institute of Research for Food Safety and Health IRC-FSH, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
Micaela Gliozzi
Department of Health Sciences, Institute of Research for Food Safety and Health IRC-FSH, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
Vincenzo Mollace
Department of Health Sciences, Institute of Research for Food Safety and Health IRC-FSH, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
Salvia rosmarinus Spenn. is a native Mediterranean shrub belonging to the Lamiaceae family and is well-known as a flavoring and spicing agent. In addition to its classical use, it has drawn attention because its biological activities, due particularly to the presence of polyphenols, including carnosic acid and rosmarinic acid, and phenolic diterpenes as carnosol. In this study, the aerial part of rosemary was extracted with a hydroalcoholic solution through maceration, followed by ultrasound sonication, to obtain a terpenoids-rich Salvia rosmarinus extract (TRSrE) and a polyphenols-rich Salvia rosmarinus extract (PRSrE). After phytochemical characterization, both extracts were investigated for their antioxidant activity through a classical assay and with electron paramagnetic resonance (EPR) for their DPPH and hydroxyl radicals scavenging. Finally, their potential beneficial effects to reduce lipid accumulation in an in vitro model of NAFLD were evaluated.
