Nature Communications (Oct 2017)
Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens
- Xiaojie Luan,
- George Belev,
- Julian S. Tam,
- Santosh Jagadeeshan,
- Noman Hassan,
- Paula Gioino,
- Nikolay Grishchenko,
- Yanyun Huang,
- James L. Carmalt,
- Tanya Duke,
- Teela Jones,
- Bev Monson,
- Monique Burmester,
- Tomer Simovich,
- Orhan Yilmaz,
- Veronica A. Campanucci,
- Terry E. Machen,
- L. Dean Chapman,
- Juan P. Ianowski
Affiliations
- Xiaojie Luan
- Department of Physiology, University of Saskatchewan
- George Belev
- Canadian Light Source Inc.
- Julian S. Tam
- Department of Medicine, Division of Respirology, Critical Care, and Sleep Medicine, University of Saskatchewan
- Santosh Jagadeeshan
- Department of Physiology, University of Saskatchewan
- Noman Hassan
- Department of Physiology, University of Saskatchewan
- Paula Gioino
- Department of Physiology, University of Saskatchewan
- Nikolay Grishchenko
- Department of Physiology, University of Saskatchewan
- Yanyun Huang
- Prairie Diagnostic Services Inc.
- James L. Carmalt
- Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan
- Tanya Duke
- Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan
- Teela Jones
- Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan
- Bev Monson
- Animal Care Unit, Western College of Veterinary Medicine, University of Saskatchewan
- Monique Burmester
- Animal Care Unit, Western College of Veterinary Medicine, University of Saskatchewan
- Tomer Simovich
- Surface Science and Technology Group, School of Chemistry, The University of Melbourne
- Orhan Yilmaz
- Department of Physiology, University of Saskatchewan
- Veronica A. Campanucci
- Department of Physiology, University of Saskatchewan
- Terry E. Machen
- Department of Molecular and Cell Biology, University of California
- L. Dean Chapman
- University of Saskatchewan, Department of Anatomy and Cell Biology
- Juan P. Ianowski
- Department of Physiology, University of Saskatchewan
- DOI
- https://doi.org/10.1038/s41467-017-00835-7
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 9
Abstract
Cystic fibrosis is caused by mutations in the CFTR chloride channel, leading to reduced airway surface liquid secretion. Here the authors show that exposure to bacteria triggers secretion in wild-type but not in pig models of cystic fibrosis, suggesting an impaired response to pathogens contributes to infection.
