The protease GtgE from Salmonella exclusively targets inactive Rab GTPases

Rudolf Wachtel; Bastian Bräuning; Sophie L. Mader; Felix Ecker; Ville R. I. Kaila; Michael Groll; Aymelt Itzen

doi:10.1038/s41467-017-02110-1

Nature Communications (Jan 2018)

The protease GtgE from Salmonella exclusively targets inactive Rab GTPases

Rudolf Wachtel,
Bastian Bräuning,
Sophie L. Mader,
Felix Ecker,
Ville R. I. Kaila,
Michael Groll,
Aymelt Itzen

Affiliations

Rudolf Wachtel: Center for Integrated Protein Science Munich (CIPSM), Department Chemistry, Technical University of Munich
Bastian Bräuning: Center for Integrated Protein Science Munich (CIPSM), Department Chemistry, Technical University of Munich
Sophie L. Mader: Center for Integrated Protein Science Munich (CIPSM), Department Chemistry, Technical University of Munich
Felix Ecker: Center for Integrated Protein Science Munich (CIPSM), Department Chemistry, Technical University of Munich
Ville R. I. Kaila: Center for Integrated Protein Science Munich (CIPSM), Department Chemistry, Technical University of Munich
Michael Groll: Center for Integrated Protein Science Munich (CIPSM), Department Chemistry, Technical University of Munich
Aymelt Itzen: Center for Integrated Protein Science Munich (CIPSM), Department Chemistry, Technical University of Munich

DOI: https://doi.org/10.1038/s41467-017-02110-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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The bacterial protease GtgE is involved in the establishment of Salmonellosis. Here the authors provide a structural and biochemical analysis of GtgE that sheds light on the molecular mechanisms of reprogramming infected host cells via site-specific proteolytic cleavage of the vesicular trafficking regulator Rab32.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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