The Role of BDNF in the Neuroimmune Axis Regulation of Mood Disorders

Yang Jin; Li Hua Sun; Wei Yang; Ran Ji Cui; Song Bai Xu

doi:10.3389/fneur.2019.00515

Frontiers in Neurology (Jun 2019)

The Role of BDNF in the Neuroimmune Axis Regulation of Mood Disorders

Yang Jin,
Li Hua Sun,
Wei Yang,
Ran Ji Cui,
Song Bai Xu

Affiliations

Yang Jin: Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, China
Li Hua Sun: Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, China
Wei Yang: Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, China
Ran Ji Cui: Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, China
Song Bai Xu: Department of Neurosurgery, First Hospital of Jilin University, Changchun, China

DOI: https://doi.org/10.3389/fneur.2019.00515
Journal volume & issue: Vol. 10

Abstract

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The neuroimmune system plays a crucial role in the regulation of mood disorders. Moreover, recent studies show that brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is a key regulator in the neuroimmune axis. However, the potential mechanism of BDNF action in the neuroimmune axis' regulation of mood disorders remains unclear. Therefore, in this review, we focus on the recent progress of BDNF in influencing mood disorders, by participating in alterations of the neuroimmune axis. This may provide evidence for future studies in this field.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

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Abstract

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