EFFICIENCY OF SOME IMMUNOMODULATORY DRUGS FOR PREVENTION OF RESPIRATORY INFECTIONS AND THEIR COMPLICATIONS IN YOUNG SCHOOLCHILDREN WITH RECURRENT RESPIRATORY INFECTIONS

Abstract

Abstract. We performed a study of efficiency for various immunocorrective drugs in a group of 548 young schoolchildren with recurrent respiratory infections. Frequency of respiratory infections and complication rates were taken as endpoints in this study. It was revealed, that preventive immunocorrection by bacterial lysates or glucosamine muramildipeptide combined with vitamin-mineral complexes may reduce frequency of respiratory infections and their complications at statistically significant levels, as well as to restore some abnormal parameters of immune profile, i.e., CD3, CD4, CD16, induced NBT test, IFNγ, TNFα and IgG. Preventive use of Echinaceae purpurae herbae succus or interferon alpha-2b in combination with vitaminmineral complexes statistically significantly reduces only the frequency of respiratory infections, and partially restores some deficient parameters of immune status (IgG, TNFα, CD16). Introduction of preventive immunocorrection in childhood institutions, with > 90 % coverage of children with recurrent respiratory diseases is associated with a decrease in frequency of respiratory infections not only in this cohort, like as among general population of the same age group.

Keywords

• recurrent respiratory diseases
• children
• immunomodulatory therapy