Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk

Alejandro Burga; Eyal Ben-David; Tzitziki Lemus Vergara; James Boocock; Leonid Kruglyak

doi:10.1038/s41467-019-10636-9

Nature Communications (Jun 2019)

Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk

Alejandro Burga,
Eyal Ben-David,
Tzitziki Lemus Vergara,
James Boocock,
Leonid Kruglyak

Affiliations

Alejandro Burga: Department of Human Genetics, Department of Biological Chemistry, and Howard Hughes Medical Institute, University of California, Los Angeles
Eyal Ben-David: Department of Human Genetics, Department of Biological Chemistry, and Howard Hughes Medical Institute, University of California, Los Angeles
Tzitziki Lemus Vergara: Department of Human Genetics, Department of Biological Chemistry, and Howard Hughes Medical Institute, University of California, Los Angeles
James Boocock: Department of Human Genetics, Department of Biological Chemistry, and Howard Hughes Medical Institute, University of California, Los Angeles
Leonid Kruglyak: Department of Human Genetics, Department of Biological Chemistry, and Howard Hughes Medical Institute, University of California, Los Angeles

DOI: https://doi.org/10.1038/s41467-019-10636-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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QTL mapping in multicellular animals usually requires generation, maintenance, and phenotyping large panels of recombinant individuals. Here, the authors develop ceX-QTL mapping, a method for fast genetic mapping via bulk selection on millions of unique recombinant C. elegans individuals.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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