SB2301-mediated perturbation of membrane composition in lipid droplets induces lipophagy and lipid droplets ubiquitination

Jinjoo Jung; Jongbeom Park; Mingi Kim; Jaeyoung Ha; Hana Cho; Seung Bum Park

doi:10.1038/s42003-023-04682-9

Communications Biology (Mar 2023)

SB2301-mediated perturbation of membrane composition in lipid droplets induces lipophagy and lipid droplets ubiquitination

Jinjoo Jung,
Jongbeom Park,
Mingi Kim,
Jaeyoung Ha,
Hana Cho,
Seung Bum Park

Affiliations

Jinjoo Jung: CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University
Jongbeom Park: CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University
Mingi Kim: CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University
Jaeyoung Ha: Department of Biophysics and Chemical Biology, Seoul National University
Hana Cho: Department of Biophysics and Chemical Biology, Seoul National University
Seung Bum Park: CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University

DOI: https://doi.org/10.1038/s42003-023-04682-9
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 13

Abstract

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The small molecule SB2301 activates lipophagy and alters lipid droplet membrane composition, with the ethanolamine-phosphate cytidylyltransferase 2 (PCYT2) being a potential target of the compound.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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