Small G Protein Regulates Virus Infection via MiRNA and Autophagy in Shrimp

Abstract

Recently, there has been a burgeoning scholarly interest in elucidating the functional significance and regulatory mechanisms underlying the involvement of small G proteins, such as Rab, in the antiviral immune response of crustaceans. Rab is a member of the small G protein family and plays a crucial role in the transport of cell membranes within eukaryotic cells. It is involved in the movement of cell membranes both within the cell and on its surface, aiding in the entry of effector proteins into specific membrane subregions. While previous research has highlighted the importance of Rab in phagosome formation and maturation, as well as the clearance of innate immune pathogens by phagocytes, its role in regulating autophagy and the antiviral mechanism remains unclear. This study focused on Rab10 and its role in the autophagy pathway within shrimp, as it pertains to defending against viral infections. MiRNA targeting Rab10 was analyzed and verified by bioinformatic methods. It was found that inhibition of miR-2c could enhance the shrimp’s ability to combat viral infections. This discovery suggests a potential new strategy for screening antiviral drugs. In summation, this investigation augments our comprehension of the antiviral mechanism associated with Rab10, illuminating its significance in the antiviral immune response of shrimp.

Keywords

• shrimp
• Rab10
• miR-2c
• autophagy
• antiviral