Journal of Community Hospital Internal Medicine Perspectives (Oct 2017)

An unusual case of chronic lymphocytic leukemia, multiple myeloma and cardiac amyloidosis

  • Dongyan Liu,
  • Hakim T. Uqdah,
  • Alisha D. Gordy

DOI
https://doi.org/10.1080/20009666.2017.1370940
Journal volume & issue
Vol. 7, no. 4
pp. 230 – 233

Abstract

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Light chain amyloidosis has very rarely been reported in association with chronic lymphocytic leukemia (CLL). We reported on a 76-years-old female who presented with simultaneous kappa-restricted chronic lymphocytic leukemia (CLL) and a lambda-restricted multiple myeloma with plasma cells causing AL amyloidosis involving the heart. While monoclonal immunoglobulins occasionallyproduced by CLL have previously been implicated in AL amyloidosis, there only a few cases reported of AL amyloidosis resulting from a distinct plasma cell dyscrasia that is not clonally related to the concurrent CLL.

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