Increase in Alcoholic Hepatitis as an Etiology for Liver Transplantation in the United States: A 2004–2018 Analysis

Nabil Noureddin, MD; Ju Dong Yang, MD; Naim Alkhouri, MD; Samantha M. Noreen, PhD; Alice E. Toll, MS; Tsuyoshi Todo, MD; Walid Ayoub, MD; Alexander Kuo, MD; Georgios Voidonikolas, MD; Honore G. Kotler, RN, PhD-c, ACNP, CCTC; Michalyn D. Pelphrey, MSN; Brenda J. Durand, RN, BSN; Kambiz Kosari, MD; Todd V. Brennan, MD; Irene Kim, MD; Andrew S. Klein, MD; Ekihiro Seki, MD, PhD; Nicholas N. Nissen, MD; Shelly C. Lu, MD; Vinay Sundaram, MD; Mazen Noureddin, MD, MHSc

doi:10.1097/TXD.0000000000001051

Transplantation Direct (Nov 2020)

Increase in Alcoholic Hepatitis as an Etiology for Liver Transplantation in the United States: A 2004–2018 Analysis

Nabil Noureddin, MD,
Ju Dong Yang, MD,
Naim Alkhouri, MD,
Samantha M. Noreen, PhD,
Alice E. Toll, MS,
Tsuyoshi Todo, MD,
Walid Ayoub, MD,
Alexander Kuo, MD,
Georgios Voidonikolas, MD,
Honore G. Kotler, RN, PhD-c, ACNP, CCTC,
Michalyn D. Pelphrey, MSN,
Brenda J. Durand, RN, BSN,
Kambiz Kosari, MD,
Todd V. Brennan, MD,
Irene Kim, MD,
Andrew S. Klein, MD,
Ekihiro Seki, MD, PhD,
Nicholas N. Nissen, MD,
Shelly C. Lu, MD,
Vinay Sundaram, MD,
Mazen Noureddin, MD, MHSc

Affiliations

Nabil Noureddin, MD: 1 School of Medicine, Department of Internal Medicine, University of Nevada, Las Vegas, Las Vegas, NV.
Ju Dong Yang, MD: 2 Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.
Naim Alkhouri, MD: 4 Arizona Liver Health, Chandler, AZ.
Samantha M. Noreen, PhD: 5 Research Department, United Network for Organ Sharing, Richmond, VA.
Alice E. Toll, MS: 5 Research Department, United Network for Organ Sharing, Richmond, VA.
Tsuyoshi Todo, MD: 6 Department of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Walid Ayoub, MD: 2 Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.
Alexander Kuo, MD: 2 Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.
Georgios Voidonikolas, MD: 6 Department of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Honore G. Kotler, RN, PhD-c, ACNP, CCTC: 6 Department of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Michalyn D. Pelphrey, MSN: 3 Department of Medicine, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Brenda J. Durand, RN, BSN: 3 Department of Medicine, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Kambiz Kosari, MD: 6 Department of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Todd V. Brennan, MD: 6 Department of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Irene Kim, MD: 6 Department of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Andrew S. Klein, MD: 6 Department of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Ekihiro Seki, MD, PhD: 2 Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.
Nicholas N. Nissen, MD: 6 Department of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Shelly C. Lu, MD: 2 Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.
Vinay Sundaram, MD: 2 Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.
Mazen Noureddin, MD, MHSc: 2 Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.

DOI: https://doi.org/10.1097/TXD.0000000000001051
Journal volume & issue: Vol. 6, no. 11
p. e612

Abstract

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Background. Changing opinions on the alcohol abstinence requirement have led to increased liver transplantation (LT) for alcoholic hepatitis (AH). We aimed to determine the trend in LT for AH in the United States and overall and graft survival rates. Methods. Adult liver-alone and liver-kidney registrations added to the Organ Procurement and Transplantation Network waiting list between 2004 and 2018 were divided into 3 periods (2004–2009, 2010–2013, 2014–2018). Kaplan-Meier survival models illustrated patient and graft survival. Results. Between 2004 and 2018, 529 AH patients were registered for and 254 received LT. By periods, 116, 73, and 340 patients were registered for and 49, 17, and 188 patients received LT, respectively, indicating a increase in LT for AH from 2014 to 2018. Yearly registrants from 2014 to 2018 were 32, 47, 51, 70, and 140, and recipients were 16, 24, 24, 38, and 88, respectively, indicating increases of 338% and 450% in registrants and recipients, respectively, since 2014. AH patients had the highest 1- and 3-year posttransplant survival (93.2% and 87.3%, respectively) and graft survival (90.4% and 84.8%, respectively) comparing to other LT recipients. Conclusions. LT for AH in the United States is at an all-time high with an increased overall patient and graft survival.

Published in Transplantation Direct

ISSN: 2373-8731 (Online)
Publisher: Wolters Kluwer
Country of publisher: United States
LCC subjects: Medicine: Surgery
Website: http://journals.lww.com/transplantationdirect/Pages/default.aspx

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