PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

Mi Kyung Park; Yixin Yao; Weiya Xia; Stephanie Rebecca Setijono; Jae Hwan Kim; Isabelle K. Vila; Hui-Hsuan Chiu; Yun Wu; Enrique González Billalabeitia; Min Gyu Lee; Robert G. Kalb; Mien-Chie Hung; Pier Paolo Pandolfi; Su Jung Song; Min Sup Song

doi:10.1038/s41467-019-08481-x

Nature Communications (Feb 2019)

PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

Mi Kyung Park,
Yixin Yao,
Weiya Xia,
Stephanie Rebecca Setijono,
Jae Hwan Kim,
Isabelle K. Vila,
Hui-Hsuan Chiu,
Yun Wu,
Enrique González Billalabeitia,
Min Gyu Lee,
Robert G. Kalb,
Mien-Chie Hung,
Pier Paolo Pandolfi,
Su Jung Song,
Min Sup Song

Affiliations

Mi Kyung Park: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
Yixin Yao: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
Weiya Xia: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
Stephanie Rebecca Setijono: Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University
Jae Hwan Kim: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
Isabelle K. Vila: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
Hui-Hsuan Chiu: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
Yun Wu: Department of Pathology, The University of Texas MD Anderson Cancer Center
Enrique González Billalabeitia: Department of Clinical Oncology, Hospital Universitario Morales Meseguer-IMIB, Universidad Católica San Antonio de Murcia-UCAM
Min Gyu Lee: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
Robert G. Kalb: Division of Neurology, Department of Pediatrics, Research Institute, Children’s Hospital of Philadelphia, University of Pennsylvania
Mien-Chie Hung: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
Pier Paolo Pandolfi: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Su Jung Song: Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University
Min Sup Song: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-019-08481-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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PTEN is a lipid phosphatase that functions as a dose-dependent tumor suppressor through the PI3K/AKT pathway. Here the authors describe a signaling feedback mechanism where PTEN stability is regulated through transcriptional upregulation of X-linked ubiquitin-specific protease 11 (USP11) via the PI3K/FOXO pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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