Journal of Evidence-Based Complementary & Alternative Medicine (Jan 2012)
Fluoride
Abstract
Fluoride is a naturally occurring element with multiple implications for human health. This review discusses its metabolism and toxicity, along with the current understanding of the mechanism of action of fluoride and its role as a safe and effective agent in the prevention of dental caries. The relationship between excessive fluoride intake during periods of dental enamel formation and the development of dental fluorosis is also reviewed.