Nature Communications (Jul 2020)

Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons

  • Jessica C. Jimenez,
  • Jack E. Berry,
  • Sean C. Lim,
  • Samantha K. Ong,
  • Mazen A. Kheirbek,
  • Rene Hen

DOI
https://doi.org/10.1038/s41467-020-17270-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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The vCA1-BA projection is enriched in shock responsive neurons, which are necessary for fear memory encoding and become correlated with a network of neurons during retrieval. Here the authors show that the magnitude of vCA1 correlated activity is proportional to memory strength and requires the shock response during encoding.