Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter

Mark D. Condon; Nicola J. Platt; Yan-Feng Zhang; Bradley M. Roberts; Michael A. Clements; Stefania Vietti-Michelina; Min-Yee Tseu; Katherine R. Brimblecombe; Sarah Threlfell; Edward O. Mann; Stephanie J. Cragg

doi:10.1038/s41467-019-12264-9

Nature Communications (Sep 2019)

Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter

Mark D. Condon,
Nicola J. Platt,
Yan-Feng Zhang,
Bradley M. Roberts,
Michael A. Clements,
Stefania Vietti-Michelina,
Min-Yee Tseu,
Katherine R. Brimblecombe,
Sarah Threlfell,
Edward O. Mann,
Stephanie J. Cragg

Affiliations

Mark D. Condon: Department of Physiology, Anatomy and Genetics, University of Oxford
Nicola J. Platt: Department of Physiology, Anatomy and Genetics, University of Oxford
Yan-Feng Zhang: Department of Physiology, Anatomy and Genetics, University of Oxford
Bradley M. Roberts: Department of Physiology, Anatomy and Genetics, University of Oxford
Michael A. Clements: Department of Physiology, Anatomy and Genetics, University of Oxford
Stefania Vietti-Michelina: Department of Physiology, Anatomy and Genetics, University of Oxford
Min-Yee Tseu: Department of Physiology, Anatomy and Genetics, University of Oxford
Katherine R. Brimblecombe: Department of Physiology, Anatomy and Genetics, University of Oxford
Sarah Threlfell: Department of Physiology, Anatomy and Genetics, University of Oxford
Edward O. Mann: Department of Physiology, Anatomy and Genetics, University of Oxford
Stephanie J. Cragg: Department of Physiology, Anatomy and Genetics, University of Oxford

DOI: https://doi.org/10.1038/s41467-019-12264-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

Dopamine release in the striatum has important roles in action selection and in disorders such as Parkinson’s disease. The authors here show that short-term plasticity of dopamine release is strongly determined by axonal activation and dopamine transporters.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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