Use of gammaglobulin in transplantation of hematopoletic stem cellas and in kidney transplant

Abstract

Intravenous immunoglobulin (IVIG) preparation comprise a pooled IgG antiboidies from the serum of thousands of donors and has been used as therapy in several pathologies such as: primary im- munodeficiency’s, autoimmune diseases, Kawasaki disease and on transplantation field to treat graft versus host disease, viral infec- tions and sensitization due to anti-donor antibodies. The anti-donor antibodies are an important risk factor for acute humoral rejections on kidney transplantation and are a very important risk factor for graft failure after hematopoietic stem cell transplantation. Using IVIG to treat patients with anti-donor antibodies might reduced the risk of acute kidney rejection and graft failure following hematopoietic stem cell transplantation.

Keywords

• GGIV
• enfermedad injerto contra huésped
• falla de injerto
• anticuerpos anti-HLA
• rechazo agudo