Acta Pharmaceutica Sinica B (Jun 2020)

Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects

  • Yan Chen,
  • Chen Chen,
  • Xiaojuan Zhang,
  • Chuanchuan He,
  • Pengxuan Zhao,
  • Minsi Li,
  • Ting Fan,
  • Ruicong Yan,
  • Yao Lu,
  • Robert J. Lee,
  • Muhammad Waseem Khan,
  • Muhammad Sarfraz,
  • Xiang Ma,
  • Tan Yang,
  • Guangya Xiang

DOI
https://doi.org/10.1016/j.apsb.2019.10.011
Journal volume & issue
Vol. 10, no. 6
pp. 1106 – 1121

Abstract

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Platinum-based chemotherapy is used for non-small cell lung cancer (NSCLC). However, it has side effects and minimum efficacy against lung cancer metastasis. In this study, platinum–curcumin complexes were loaded into pH and redox dual-responsive nanoparticles (denoted as Pt–CUR@PSPPN) to facilitate intracellular release and synergistic anti-cancer effects. Pt–CUR@PSPPN was prepared by a nano-precipitation method and had a diameter of ∼100 nm. The nanoparticles showed increased anti-cancer effects both in vivo and in vitro. In addition, Pt–CUR@PSPPN blocked PI3K/AKT signal transduction pathway and inhibited MMP2 and VEGFR2, resulting in enhanced anti-metastatic activity. Furthermore, reduced side effects were also observed. In conclusion, Pt–CUR@PSPPN provided a novel and attractive therapeutic strategy for NSCLC.

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