Nature Communications (Aug 2019)
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
- Tânia D. F. Costa,
- Ting Zhuang,
- Julie Lorent,
- Emilia Turco,
- Helene Olofsson,
- Miriam Masia-Balague,
- Miao Zhao,
- Parisa Rabieifar,
- Neil Robertson,
- Raoul Kuiper,
- Jonas Sjölund,
- Matthias Spiess,
- Pablo Hernández-Varas,
- Uta Rabenhorst,
- Pernilla Roswall,
- Ran Ma,
- Xiaowei Gong,
- Johan Hartman,
- Kristian Pietras,
- Peter D. Adams,
- Paola Defilippi,
- Staffan Strömblad
Affiliations
- Tânia D. F. Costa
- Department of Biosciences and Nutrition, Karolinska Institutet
- Ting Zhuang
- Department of Biosciences and Nutrition, Karolinska Institutet
- Julie Lorent
- Department of Oncology-Pathology, Karolinska Institutet
- Emilia Turco
- Department of Genetics, Biology and Biochemistry, University of Torino
- Helene Olofsson
- Department of Biosciences and Nutrition, Karolinska Institutet
- Miriam Masia-Balague
- Department of Biosciences and Nutrition, Karolinska Institutet
- Miao Zhao
- Department of Biosciences and Nutrition, Karolinska Institutet
- Parisa Rabieifar
- Department of Biosciences and Nutrition, Karolinska Institutet
- Neil Robertson
- Beatson Institute for Cancer Research
- Raoul Kuiper
- Department of Laboratory Medicine, Karolinska Institutet
- Jonas Sjölund
- Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University
- Matthias Spiess
- Department of Biosciences and Nutrition, Karolinska Institutet
- Pablo Hernández-Varas
- Department of Biosciences and Nutrition, Karolinska Institutet
- Uta Rabenhorst
- Department of Biosciences and Nutrition, Karolinska Institutet
- Pernilla Roswall
- Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Ran Ma
- Department of Oncology-Pathology, Karolinska Institutet
- Xiaowei Gong
- Department of Biosciences and Nutrition, Karolinska Institutet
- Johan Hartman
- Department of Oncology-Pathology, Karolinska Institutet
- Kristian Pietras
- Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University
- Peter D. Adams
- Beatson Institute for Cancer Research
- Paola Defilippi
- Department of Genetics, Biology and Biochemistry, University of Torino
- Staffan Strömblad
- Department of Biosciences and Nutrition, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-019-11510-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Oncogene induced senescence protects cells from unrestricted growth and cancer. Here, the authors show that PAK4 overrides this senescence in breast cancer cells through phosphorylation of RELB, thereby inhibiting transcription of the senescence regulator C/EBPβ.
