Nature Communications (Dec 2020)
Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
Abstract
Mammalian skeletal muscle is composed of multinucleated myofibers, containing hundreds of nuclei that coordinate cellular function. Here, the authors show that single-nucleus RNA-sequencing reveals rare and emergent myonuclear populations, and uncovers dynamic transcriptional heterogeneity in development and aging.