Spirulina polysaccharide induces the metabolic shifts and gut microbiota change of lung cancer in mice

Yingfang Lu; Bo Peng; Yuqi Lin; Qianmin Lin; Xuewei Xia; Saiyi Zhong; Lianxiang Luo; Riming Huang

Current Research in Food Science (Jan 2022)

Spirulina polysaccharide induces the metabolic shifts and gut microbiota change of lung cancer in mice

Yingfang Lu,
Bo Peng,
Yuqi Lin,
Qianmin Lin,
Xuewei Xia,
Saiyi Zhong,
Lianxiang Luo,
Riming Huang

Affiliations

Yingfang Lu: Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China
Bo Peng: State Key Laboratory of Organic Geochemistry, Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China, CAS Center for Excellence in Deep Earth Science, Guangzhou, 510640, China; University of Chinese Academy of Sciences, Beijing, 100049, China
Yuqi Lin: Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China
Qianmin Lin: Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China
Xuewei Xia: Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China
Saiyi Zhong: College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Province Engineering Laboratory for Marine Biological Products, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang, 524088, China
Lianxiang Luo: The Marine Biomedical Research Institute, Guangdong Medical University, The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, 524000, China; Corresponding author.
Riming Huang: Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China; Corresponding author.

Journal volume & issue: Vol. 5
pp. 1313 – 1319

Abstract

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A polysaccharide obtained from Spirulina (PSP) and its effect on lung cancer in mice was investigated. Our results indicate that the tumor volume and weight of the lung cancer-bearing mice treated with PSP decreased significantly. Metabolite analysis showed that 27 differential accumulated metabolites (DAMs) changed significantly, in which 24 DAMs increased while 3 DAMs decreased. KEGG enrichment results showed that these differential metabolites were enriched significantly in the high-affinity IgE receptor (FcεRI) signaling pathway and arachidonic acid metabolism. In addition, PSP modulated gut microbiota of the lung cancer-bearing mice. PSP increased the abundance of Lactobacillus, Allobaculum, Alloprevotella, and Olsenella, decreasing Bacteroides and Acinetobacter. The results might be related to suppressing lung cancer. Based on our study, we hypothesized that PSP inhibited lung cancer through FcεRI signaling pathway and arachidonic acid metabolism and regulated the balance of gut microbiota. Nevertheless, the relationship between these two pathways and gut microbiota needs further study.

Published in Current Research in Food Science

ISSN: 2665-9271 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply; Technology: Chemical technology: Food processing and manufacture
Website: https://www.journals.elsevier.com/current-research-in-food-science

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