The Peri-Implant Microbiome—A Possible Factor Determining the Success of Surgical Peri-Implantitis Treatment?

Jarno Hakkers; Lei Liu; Diederik F. M. Hentenaar; Gerry M. Raghoebar; Arjan Vissink; Henny J. A. Meijer; Lisa Walters; Hermie J. M. Harmsen; Yvonne C. M. de Waal

doi:10.3390/dj12010020

Dentistry Journal (Jan 2024)

The Peri-Implant Microbiome—A Possible Factor Determining the Success of Surgical Peri-Implantitis Treatment?

Jarno Hakkers,
Lei Liu,
Diederik F. M. Hentenaar,
Gerry M. Raghoebar,
Arjan Vissink,
Henny J. A. Meijer,
Lisa Walters,
Hermie J. M. Harmsen,
Yvonne C. M. de Waal

Affiliations

Jarno Hakkers: Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Lei Liu: Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Diederik F. M. Hentenaar: Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Gerry M. Raghoebar: Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Arjan Vissink: Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Henny J. A. Meijer: Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Lisa Walters: Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Hermie J. M. Harmsen: Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Yvonne C. M. de Waal: Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands

DOI: https://doi.org/10.3390/dj12010020
Journal volume & issue: Vol. 12, no. 1
p. 20

Abstract

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The objective was to assess the effect of peri-implantitis surgery on the peri-implant microbiome with a follow-up of one year. A total of 25 peri-implantitis patients in whom non-surgical treatment has failed to solve peri-implantitis underwent resective surgical treatment. Their peri-implant pockets were sampled prior to surgical treatment (T0) and one year post treatment (T12). The natural dentition was sampled to analyse similarities and differences with the peri-implantitis samples. Treatment success was recorded. The change in microbial relative abundance levels was evaluated. The microbiota was analysed by sequencing the amplified V3-V4 region of the 16S rRNA genes. Sequence data were binned to amplicon sequence variants that were assigned to bacterial genera. Group differences were analysed using principal coordinate analysis, Wilcoxon signed rank tests, and t-tests. Beta diversity analyses reported a significant separation between peri-implantitis and natural dentition samples on T0 and T12, along with significant separations between successfully and non-successfully treated patients. Eubacterium was significantly lower on T12 compared to T0 for the peri-implantitis samples. Treponema and Eubacterium abundance levels were significantly lower in patients with treatment success on T0 and T12 versus no treatment success. Therefore, lower baseline levels of Treponema and Eubacterium seem to be associated with treatment success of peri-implantitis surgery. This study might aid clinicians in determining which peri-implantitis cases might be suitable for treatment and give a prognosis with regard to treatment success.

Published in Dentistry Journal

ISSN: 2304-6767 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Dentistry
Website: http://www.mdpi.com/journal/dentistry

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