Safety and efficacy of intracameral triamcinolone in postcataract inflammation

Abstract

Objective: To evaluate the efficacy and safety of intracameral triamcinolone on post-cataract surgery inflammation compared with topical 1% prednisolone acetate. Methods: Eighteen eyes of 18 patients underwent phacoemulsification with intraocular-lens implantation. They were randomly assigned to 2 treatment groups: the control group received 1% prednisolone acetate postoperatively for 1 month; the triamcinolone group received 0.4 mg in 0.1 ml solution of triamcinolone acetonide intraoperatively. Main outcome measures were anterior-chamber (AC) cells, conjunctival hyperemia, corneal edema, and intraocular pressure (IOP). Results: Significant difference in preoperative and postoperative AC cells in both the control (p < 0.001) and triamcinolone (p = 0.001) groups was seen, but no difference postoperatively between the 2 groups (0.98 vs. 0.94 respectively). No difference in postoperative conjunctival hyperemia or increase in IOP was seen in both groups. Snow-globe effect and pseudohypopyon were transiently observed in the triamcinolone group. Conclusion: Intracameral triamcinolone is a safe alternative to topical 1% prednisolone acetate in controlling postoperative inflammation.

Keywords

• triamcinolone
• postoperative inflammation
• intracameral
• cataract surgery
• steroids