Nature Communications (Mar 2022)

A computational model of neurodegeneration in Alzheimer’s disease

  • D. Jones,
  • V. Lowe,
  • J. Graff-Radford,
  • H. Botha,
  • L. Barnard,
  • D. Wiepert,
  • M. C. Murphy,
  • M. Murray,
  • M. Senjem,
  • J. Gunter,
  • H. Wiste,
  • B. Boeve,
  • D. Knopman,
  • R. Petersen,
  • C. Jack

DOI
https://doi.org/10.1038/s41467-022-29047-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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Low-dimensional representations of functional brain anatomy relevant for dementia syndromes may exist. Here the authors propose a computational model of mental functions to catalogue this anatomy in Alzheimer’s and related dementias.